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As shown in this Review Article, Cathepsins could be very efficient tools, leverages or even actuators for the design of advanced drug de-livery systems. It has been shown that these systems were sensitive to the presence of a broad spectrum of different Cathepsins, leading to enhanced therapeutic benefit and imaging capabilities. Among the nu-merous Cathepsin-sensitive conjugates reported so far, some of them have shown promising results and even reached advanced clinical tri-als. However, a great deal of work remains especially regarding the lack of site specificity and the still limited understanding of the biolog-ical roles of some proteases. These limitations must be resolved to de-velop optimized conjugates and offer more prominent clinical candidates.
Also, it 50-07-7 has been demonstrated that cysteine Cathepsin proteases can act as regulators for cancer progression as well as therapeutic response . It means that they can either promote tumor growth or suppress tumor depending upon the environment. However, more clinical inves-tigations must be performed to have a complete and accurate picture of the situation in vivo.
Conflict of interest
The authors confirm that there are no known conflicts of interest as-sociated with the content of this article.
D.D. thank to Indo French Centre for Promotion of Advanced Re-search (IFCPAR/CEFIPRA) for Raman Charpak Fellowship 2017 and CSIR-New Delhi, India for her research fellowship. This research work was financially supported by DST EMR/2016/002304 and DST EEQ/ 2016/000102 and IIIM communication no. IIIM/2244/2018. CNRS and Université Paris-Sud are also acknowledged for financial support.
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